HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 2-Chloro-3-nitrobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(Bromomethyl)-2-chloro-3-nitrobenzene | HCID 18363045 | — |
| Catalyst | Benzenesulfonic acid, 4-methyl-, silver(1+) salt (1:1) | HCID 85606 | — |
| Product | 2-Chloro-3-nitrobenzaldehyde | HCID 12667713 | 20% |
Reaction Steps
2-Chloro-3-nitrobenzaldehyde (150 mg, 20%) was prepared by reaction of 1-bromomethyl-2-chloro-3-nitrobenzene (1.0 g, 3.9 mmol) with silver p-toluenesulfonate (1.94 g, 1.75 equiv.) in DMSO in the presence of Et3N (4 mL, 7 equiv.) at rt for 1 hour.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117881 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-3d1f8fa0a4094acbbd9fb996f554ad01 |
| Source note | uspto-grants-2000_09 |