HCID 131721986, compound → HCID 70107440, compound

Participants

Reaction Steps

A solution of Example 190 (0.33 g, 0.55 mmol) in DCM (30 mL) was treated with zinc bromide (0.63 g, 5 equiv.) for 16 hours at 30° C. A gummy solid was formed. Extraction with DCM:MeOH, washing with water, drying over Na2SO4 and recrystallization from iPrOH gave the title compound as white crystals in a 98% yield. MP: 145° C. Analysis for C31H31N3O3. 0.2H2O: Calculated: C,74.89; H,6.37; N,8.45; Found: C,74.90; H,6.70; N,8.49%. [α]D20 =-337 (c=0.4, MeOH).

Provenance & Evidence