HCID 23298443, compound → HCID 23298415, compound

Participants

Reaction Steps

To 5-nitro-2-(methyl)(phenylmethyl)aminoindane hydrochloride (1.08 g, 339 mmol) in 85% acetic acid/water was added zinc powder (3.0 g). The mixture was stirred for 1 minute, filtered through celite and concentrated. The concentrate was neutralized with 2N NaOH and extracted with ethyl acetate (3×50 ml). The combined extracts were washed with water, dried over magnesium sulfate, and reduced to a syrup. The oil was treated with IPA/HCl, concentrated and used immediately in the next step.

Provenance & Evidence