3-Nitrophenylacetic acid → 2-[(3Nitrophenyl)acetamido]butyric acid iso-butyl ester

HRID 1953582Notes

Reaction equation

HRID 1953582 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11]([OH:13])=O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[NH2:14][CH:15]([CH2:23][CH3:24])[C:16]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[O:17]>>[CH2:19]([O:18][C:16](=[O:17])[CH:15]([NH:14][C:11](=[O:13])[CH2:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH2:23][CH3:24])[CH:20]([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 158763-Nitrophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 539659122-[(3Nitrophenyl)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure I above and using 3-nitrophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-fd4e71c903834c219300b9ac77935a6e
Source dataset
uspto-grants-2000_09
Patent number
US06117901

Reaction notes

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