2-Thiopheneacetic acid → 2-[(2-Thienyl)acetamido]butyric acid isobutyl ester

HRID 1953592Notes

Reaction equation

HRID 1953592 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([OH:9])=O.[NH2:10][CH:11]([CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])=[O:13]>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]([NH:10][C:7](=[O:9])[CH2:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[CH2:19][CH3:20])[CH:16]([CH3:17])[CH3:18]

Participants

3

Reactant 2

HCID 159702-Thiopheneacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 544436822-[(2-Thienyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I above and using 2-thiopheneacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J above), the tide compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customthe tide compound was prepared
  2. customThe reaction was monitored by tlc on silica gel and purification
  3. filtrationwas by filtration

Sources & evidence

ORD record
ord-5bb4e72326a544b28941722401367d38
Source dataset
uspto-grants-2000_09
Patent number
US06117901

Reaction notes

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