HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-[4-{2-(7-Azaindol-1-yl)ethoxy]benzyl}thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 5-{4-[2-(7-Azaindol-1-yl)ethoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione | HCID 23298299 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-[4-{2-(7-Azaindol-1-yl)ethoxy]benzyl}thiazolidine-2,4-dione | HCID 10737699 | 55.8% |
Reaction Steps
A procedure similar to that described in Example 2 was repeated, except that 2.50 g of 5-{4-[2-(7-azaindol-1-yl)ethoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione (prepared as described in Preparation 19), 50 ml of methylene chloride and 3.1 ml of trifluoroacetic acid were used, to give 0.84 g of the title compound, melting at 200.0-202.4° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117893 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-466c7e5963964abc80ce20b57772a816 |
| Source note | uspto-grants-2000_09 |