HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → HCID 23298307, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Reactant | 2-(2,3-dihydro-1H-indol-1-yl)ethan-1-ol | HCID 23298305 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 23298307 | HCID 23298307 | 59% |
Reaction Steps
A procedure similar to that described in Preparation 4 was repeated, except that 240 mg of 2-(indolin-1-yl)-ethanol (prepared as described in Preparation 9), 690 mg of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione, 0.37 ml of tributylphosphine, 370 mg of 1,1'-(azodicarbonyl)dipiperidine and 5 ml of anhydrous tetrahydrofuran were used, to give 530 mg of the title compound having Rf=0.88 (on silica gel thin layer chromatography using a 2:1 by volume mixture of hexane and ethyl acetate as the developing solvent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117893 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-5a32094489cb45bebd22993f61a9521a |
| Source note | uspto-grants-2000_09 |