HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → 5-[4-(3-Methylimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Reactant | (3-methyl-3H-imidazo[4,5-b]pyridin-2-yl)methanol | HCID 10702152 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-[4-(3-Methylimidazo[5,4-b]pyridin-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione | HCID 10746302 | 16% |
Reaction Steps
A procedure similar to that described in Preparation 4 was repeated, except that 0.5 g of 3-methylimidazo-[5,4-b]pyridin-2-ylmethanol (prepared as described in Preparation 15), 1.43 g of 5-(4-hydroxybenzyl) -3-triphenylmethylthiazolidine-2,4-dione, 0.83 ml of tributylphosphine, 0.773 g of 1,1'-(azodicarbonyl) dipiperidine and 80 ml of benzene were used, to give 0.3 g of the title compound, melting at 97-102° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117893 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-83ccee31c00148f3ad1cbeeda67c8bd3 |
| Source note | uspto-grants-2000_09 |