HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Alcohol → 6-Benzyloxy-2-methylamino-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Alcohol | HCID 244 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-chloro-N-methyl-3-nitropyridin-2-amine | HCID 10750094 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Benzyloxy-2-methylamino-3-nitropyridine | HCID 10491498 | — |
Reaction Steps
A procedure similar to that described in Preparation 88 was repeated, except that 7.00 g of 6-chloro-2-methylamino-3-nitropyridine (prepared as described in Preparation 66), 1.79 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 4.3 ml of benzyl alcohol and 150 ml of dimethylformamide were used. After working up the product as described in Preparation 88, the resulting crude product was crystallized by trituration with isopropanol, to give 9.02 g of the title compound, melting at 149° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117893 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-983c9cbb34e1414ba7fc942d146927c2 |
| Source note | uspto-grants-2000_09 |