HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 6-Ethoxy-2-methylamino-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-chloro-N-methyl-3-nitropyridin-2-amine | HCID 10750094 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Ethoxy-2-methylamino-3-nitropyridine | HCID 10631783 | — |
Reaction Steps
A procedure similar to that described in Preparation 88 was repeated, except that 6.00 g of 6-chloro-2-methylamino-3-nitropyridine (prepared as described in Preparation 66), 1.54 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 2.1 ml of ethanol and 150 ml of dimethylformamide were used. After working up the product as described in Preparation 88, the resulting crude product was crystallized by trituration with ethanol, to give 5.10 g of the title compound, melting at 101° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117893 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-3730bf30d2ea4c04b83e805f432aad30 |
| Source note | uspto-grants-2000_09 |