HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 6-Isopropoxy-2-methylamino-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6-chloro-N-methyl-3-nitropyridin-2-amine | HCID 10750094 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Isopropoxy-2-methylamino-3-nitropyridine | HCID 10846172 | — |
Reaction Steps
A procedure similar to that described in Preparation 88 was repeated, except that 6.00 g of 6-chloro-2-methylamino-3-nitropyridine (prepared as described in Preparation 66), 1.54 g of sodium hydride (as a 55% by weight dispersion in mineral oil), 2.7 ml of isopropanol and 150 ml of dimethylformamide were used. After working up the product as described in Preparation 88, the resulting crude product was crystallized by trituration with isopropanol, to give 6.10 g of the title compound, melting at 75-76° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117893 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-3feb9d3e85b343219401f325eae6613f |
| Source note | uspto-grants-2000_09 |