Methanol → HCID 23298054, compound

HRID 1953767Notes

Reaction equation

HRID 1953767 reaction equation
Cl[C:2]1[C:11](Cl)=[N:10][C:9]2[C:4](=[CH:5][C:6]([Cl:14])=[CH:7][C:8]=2[CH3:13])[N:3]=1.[CH3:15][O-:16].[Na+].[CH3:18][OH:19]>>[Cl:14][C:6]1[CH:5]=[C:4]2[C:9]([N:10]=[C:11]([O:19][CH3:18])[C:2]([O:16][CH3:15])=[N:3]2)=[C:8]([CH3:13])[CH:7]=1

Participants

4

Reactant 3

HCID 887Methanol2×HCID 10942334Sodium MethoxideHCID 23298039HCID 23298039, compound

Product 1

HCID 23298054HCID 23298054, compound

Conditions

Temperature
0 °C

Procedure

30 g (0.121 mol) of 2,3,7-trichloro-5-methylquinoxaline are introduced into 330 ml of methanol under argon at room temperature. 67.9 ml (0.364 mmol) of an about 5.4 molar solution of sodium methoxide in methanol is added dropwise to this and the mixture is stirred at reflux for 4.5 hours. After cooling to 0° C., the suspension is filtered off on a suction filter, and the filter residue is washed with methanol and dried in vacuo at 60° C. The title compound is obtained as brownish crystals of m.p. 94-96° C.

Workup

  1. temperatureat reflux for 4.5 hours
  2. filtrationthe suspension is filtered off on a suction
  3. filtrationfilter
  4. washthe filter residue is washed with methanol
  5. customdried in vacuo at 60° C

Sources & evidence

ORD record
ord-de95f72d2e82407db1ad76bfd1a35b09
Source dataset
uspto-grants-2000_09
Patent number
US06117873

Reaction notes

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