HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium hydroxide, monohydrate → 4-[4-(Carboxy)methoxy-3,5-dimethyphenyl]-2-methyl-1(2H)phthalazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | [2,6-Dimethyl-4-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-phenoxy]-acetic acid methyl ester | HCID 2800809 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[4-(Carboxy)methoxy-3,5-dimethyphenyl]-2-methyl-1(2H)phthalazinone | HCID 70008385 | 93.2% |
Reaction Steps
Lithium hydroxide monohydrate (0.22 g) was added to a solution of example 107 (1.52 g) in aqueous tetrahydrofuran (1:1 50 ml) and the reaction stirred 18 h, the mixture was the concentrated in vacuo and the residual slurry acidified with 10% hydrochloric acid. The resulting precipitate was collected to give the title compound as a white solid (1.36 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06118001 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-ed14d1d22ddb470eb3c1b51353d1d6aa |
| Source note | uspto-grants-2000_09 |