Dichloromethane → 1-Chloro-2-methylpropyl propanoate

Participants

Reaction Conditions

Reaction Steps

To freshly fused zinc chloride (41 mg) in methylene chloride (10 mL) was added propionyl chloride (5.0 g, 54.0 mmol). The reaction was cooled to 10° C. and isobutyraldehyde (3.89 g, 54.0 mmol) was added dropwise maintaining the temperature at 25° C. Once the addition was complete, the reaction was stirred for one hour at room temperature. The reaction mixture was washed with 20% sodium acetate and the organic phase was concentrated in vacuo to provide product of sufficient purity.

Provenance & Evidence