Diisopropylethylamine → HCID 70067440, compound

Participants

Reaction Conditions

Reaction Steps

The Preparation (S)-2-(Cyclohexyl-methyl-amino)-4-methyl-pentanoic Acid (IId) ##STR31## Step i: N-Me-O-Benzyl-L-Leucine (3.6 g, 15.3 mmol) was dissolved in THF (77 mL) and treated with diisopropylethylamine (21 mL, 122 mmol) and 3-bromo-cyclohexene (3.5 mL, 30.6 mmol). The reaction was heated to 50° C. for 2 days. The reaction was filtered, and the solution was concentrated. The residue was chromatographed on silica gel eluting with 8% ethyl acetate/hexanes to give 2.75 g (57%) of (S)-2-(cyclohexenyl-methyl-amino)-4-methyl-pentanoic acid benzyl ester.

Provenance & Evidence