Diisopropylethylamine → HCID 131721993, compound

Participants

Reaction Conditions

Reaction Steps

4-Methyl-2-methylamino-pentanoic acid [2-(4-benzyloxy-phenyl)-1-tert-butylcarbamoyl-ethyl]-amide (Example 35) (1.0 mmol) was dissolved in THF (10 mL) and treated with 3-bromocyclohexene (1.5 mmol) and diisopropylethylamine (3 mmol). The reaction was stirred at 50° C. for 18 hours. Then the reaction mixture was allowed to cool to room temperature and concentrated to dryness. The residue was chromatographed on silica gel eluting with a gradient of 10-30% acetone/CH2Cl2 to give the title compound with the yields of 50%.

Provenance & Evidence