4-Bromo-1,2-difluorobenzene → 3-(3,4-Difluorophenyl)thiophene

HRID 1953932Notes

Reaction equation

HRID 1953932 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)[CH:5]=[C:6](F)[C:7]=1[F:8].BrC1C=CC(F)=C(F)C=1.BrC1C=C(F)C(F)=C(F)C=1>>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 3

HCID 676754-Bromo-1,2-difluorobenzeneHCID 6114091-Bromo-3,4,5-trifluorobenzeneHCID 232955283-(3,4,5-Trifluorophenyl)thiophene

Product 1

HCID 227436983-(3,4-Difluorophenyl)thiophene

Procedure

The same procedures set forth above in Example A(1)(a) for synthesizing 3(3,4,5-trifluorophenyl)thiophene were followed, with the exception that 1-bromo-3,4-difluorobenzene was substituted for 1-bromo-3,4,5-trifluorobenzene as the 1-bromo-substituted fluorobenzene.

Sources & evidence

ORD record
ord-8597bf0512164ecd927ec18efcde0b09
Source dataset
uspto-grants-2000_09
Patent number
US06120940

Reaction notes

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