Potassium Carbonate → HCID 11177155, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-hydroxy-2-(trifluoromethyl)thiophene (0.50 g, 2.98 mmol) and 6-chloro-4-methyl-2-(α,α,α-trifluoro-p-tolyl)pyrimidine (0.31g, 2.98 mmol) in dimethylformamide is treated with K2CO3 (0.62 g, 4.47 mmol), heated at 100° C. for 17 hours, cooled to room temperature and diluted with water. The resultant reaction mixture is extracted with ether. The ether extracts are combined, washed sequentially with water and brine, dried over MgSO4 and concentrated in vacuo to give a brown solid residue. The residue is chromatographed (silica gel, ethyl acetate/hexanes, 20/80) to give the title product as a light yellow solid, 0.88 g (73% yield), mp 83.5-85° C., identified by 1HNMR, 13CNMR, 19FNMR, mass spectral and elemental analyses.

Provenance & Evidence