Methanol → HCID 23295689, compound

Participants

Reaction Steps

A solution of 4-Chloro-5-ethyl-2-(α,α,α-trifluoro-p-tolyl)-6-{[5-(trifluoromethyl)-3-thienyl]oxy}pyrimidine (1.06 g, 2.34 mmol) in a 1:1 mixture of methanol:ethyl acetate is treated with triethylamine (0.80 ml, 5.86 mmol) and 10% Pd-C (0.32 g, 30 wt %). The resultant mixture is placed on a PARR hydrogenator at 50 psi for 2 hours (reaction is complete by TLC). The resultant mixture is filtered. The filtrate is concentrated. The 20/80) to give the title product as a white solid, 0.69 9 (70%), mp 67-68° C. identified by 1HNMR, 13CNMR, 19FNMR, mass spectral and elemental analyses.

Provenance & Evidence