Sodium Acetate → HCID 70231894, compound

HRID 1953996Notes

Reaction equation

Br[CH:2](Br)[C:3]([C:5]([F:8])([F:7])[F:6])=[O:4].C([O-])(=O)C.[Na+].[Cl:15][C:16]1[C:21]([O:22][C:23]2[N:28]=[CH:27][CH:26]=[CH:25][N:24]=2)=[CH:20][C:19]([NH:29][NH2:30])=[C:18]([F:31])[CH:17]=1>O>[Cl:15][C:16]1[C:21]([O:22][C:23]2[N:24]=[CH:25][CH:26]=[CH:27][N:28]=2)=[CH:20][C:19]([NH:29][N:30]=[CH:2][C:3](=[O:4])[C:5]([F:8])([F:7])[F:6])=[C:18]([F:31])[CH:17]=1

Participants

Conditions

Temperature: 80 °C

Procedure

1,1-Dibromo-3,3,3-trifluoroacetone (0.162 g) was added to a solution of sodium acetate (0.162 g) in water (0.5 ml) and the solution heated at 80° C. for 20 minutes. It was cooled to 0° C. and 4-chloro-2-fluoro-5-(pyrimidyloxy)-phenylhydrazine hydrachloride (0.15 g) was added. After stirring at room temperature for 2 hour the reaction mixture was processed to give 3,3,3-trifluoro-2-oxopropanal 4-chloro-2-fluoro-5-(pyrimidyloxy)-phenylhydrazone (0.122 g) mp=188-90° C.

Workup

temperatureIt was cooled to 0° C.

Sources & evidence

ORD record: ord-05d60bdca5414db6a744c446e9f59ae6
Source dataset: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06121201

Reaction notes

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