HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 5-Amino-4-fluoro-2-(1-imidazolyl)nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,4-Difluoro-5-nitroaniline | HCID 2758312 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Amino-4-fluoro-2-(1-imidazolyl)nitrobenzene | HCID 23295821 | — |
Reaction Steps
12 g (0.068 mol) of 5-amino-2,4-difluoronitrobenzene were slowly added at 0° C. to a solution of 4.7 g of imidazole (0.069 mol) and 2.1 g of sodium hydride (80% in oil; 0.07 mol) and then stirred at this temperature for several hours. The mixture was then diluted with water and extracted several times with methylene chloride. The residue after drying and evaporation was recrystallized from isopropanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06121265 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-ae16d0c9eb5d41978167ef239ba9d959 |
| Source note | uspto-grants-2000_09 |