Nitric Acid → HCID 15480111, compound

Participants

Reaction Steps

With ice-cooling, 1-(4-aminobutyl)-7-(1H-imidazol-1-yl)-2,3(1H,4H)-quinoxalinedione dihydrochloride (1.00 g) was dissolved in concentrated sulfuric acid (10 ml) to which was subsequently added dropwise fuming nitric acid (94 μl). The reaction solution was gradually warmed up to room temperature and stirred overnight. Ice water was added to the reaction solution, followed by neutralization using 15% sodium hydroxide aqueous solution. The thus precipitated solid was collected by filtration and dried to give 1-(4-aminobutyl)-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)-quinoxalinedione (0.40 g).

Provenance & Evidence