HCID 15896001, compound → HCID 15896002, compound

HRID 1954052Notes

Reaction equation

HRID 1954052 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[CH2:12][C@H:11]([C:15]([O:17]CC2C=CC=CC=2)=[O:16])[N:10]([S:25]([C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)(=[O:27])=[O:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[CH2:1]([N:8]1[C:13](=[O:14])[CH2:12][C@H:11]([C:15]([OH:17])=[O:16])[N:10]([S:25]([C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)(=[O:27])=[O:26])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 15896001HCID 15896001, compound

Product 1

HCID 15896002HCID 15896002, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of benzyl l-benzyl-3-[(4-methoxyphenyl)sulfonyl]-6-oxo-hexahydro-pyrimidine-4(R)-carboxylate (518 mg, 1.0 mmol) and 10% Pd/C (50 mg) in methanol (25 mL) is stirred under hydrogen atmosphere for 45 minutes. The mixture is filtered over celite and the filtrate is collected and concentrated under reduced pressure to give 1-benzyl-3-[(4-methoxyphenyl)sulfonyl]-6-oxo-hexahydro-pyrimidine-4(R)-carboxylic acid as a glassy solid.

Workup

  1. filtrationThe mixture is filtered over celite
  2. customthe filtrate is collected
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9b4a897288a84b1e85cfe100a67fe150
Source dataset
uspto-grants-2000_09
Patent number
US06121258

Reaction notes

Loading…