1-ethylpiperidine-4-carboxylic acid.HCl → HCID 21202707, compound

HRID 1954078Notes

Reaction equation

HRID 1954078 reaction equation
[ClH:1].[CH2:2]([N:4]1[CH2:12][CH2:11][CH:7]([C:8](O)=[O:9])[CH2:6][CH2:5]1)[CH3:3]>S(Cl)(Cl)=O>[ClH:1].[CH2:2]([N:4]1[CH2:12][CH2:11][CH:7]([C:8]([Cl:1])=[O:9])[CH2:6][CH2:5]1)[CH3:3]

Participants

3

Reactant 1

HCID 450750301-ethylpiperidine-4-carboxylic acid.HCl

Product 1

HCID 21202707HCID 21202707, compound

Reagents, catalysts & solvents 1

HCID 24386Thionyl ChlorideSolvent

Procedure

1-Ethyl-isonipecotic acid hydrochloride (0.95 g) was suspended in thionyl chloride (8 ml) and the mixture was stirred and heated under reflux for 3 hours to give a clear yellow solution. The thionyl chloride was removed by evaporation under reduced pressure and the resulting residue was suspended in toluene (5 ml) and the toluene was removed by evaporation under reduced pressure to give 1-ethyl-isonipecotoyl chloride hydrochloride as a white solid.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 3 hours
  3. customto give a clear yellow solution
  4. customThe thionyl chloride was removed by evaporation under reduced pressure
  5. customthe toluene was removed by evaporation under reduced pressure

Sources & evidence

ORD record
ord-a0791ea4756c48a18e64b934ad65e643
Source dataset
uspto-grants-2000_09
Patent number
US06121281

Reaction notes

Loading…