Ethyl 1-methylpiperidine-3-carboxylate → 1-methylpiperidine-3-carboxylic Acid

Participants

Reaction Steps

(±)-Ethyl N-methylnipecotate (5.0 g) was dissolved in 5M hydrochloric acid (100 ml) and stirred at room temperature for 16 h. The solution was then evaporated at reduced pressure and the residue re-evaporated from toluene (×2). Trituration gave the hydrochloride salt of (±)-N-methylnipecotic acid as a white solid (3.91 g).

Provenance & Evidence