Bromine → 3-Bromo-6-methoxy-2-(4-methoxyphenyl)-benzo[b]thiophene

Participants

Reaction Steps

A slurry of 2-(4-methoxyphenyl)-6-methoxybenzo[b]thiophene 100 g (370 mmol) in 1 L of CHCl3 was heated to reflux then removed from the heat. A solution of 19.3 mL (370 mmol) of bromine in 170 mL of carbon tetrachloride was added dropwise as the solution slowly cooled to room temperature. The resulting mixture was concentrated to dryness in vacuo to yield 129 g of the title compound as brown solid.

Provenance & Evidence