HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-indolyl-3-propylazide → 5-Fluoro-indolyl-3-propylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-indolyl-3-propylazide | HCID 54358969 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Fluoro-indolyl-3-propylamine | HCID 69948430 | 121.8% |
Reaction Steps
A solution of 5-fluoro-indolyl-3-propylazide (8 g, 0.037 mol) and 10% palladium on carbon in ethanol was hydrogenated at 50 psi for 16 hours. The catalyst was filtered and the solvent removed under vacuum. The celite was washed with methanol (300 ml) and the solvent was removed under vacuum. Chromatography (15% methanol-methylene chloride plus ammonium hydroxide) afforded 4.33 g (61%) of product as a yellow solid: mp 82-84.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06121307 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-81c9fd9dac2a4cb9b8e3e7d862316920 |
| Source note | uspto-grants-2000_09 |