1H-indole-3-propylamine → HCID 9862968, compound

HRID 1954249Notes

Reaction equation

HRID 1954249 reaction equation
[C:1]1([O:11][CH2:12][CH2:13]Cl)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([CH2:24][CH2:25][CH2:26][NH2:27])=[CH:16]1>>[NH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]([CH2:24][CH2:25][CH2:26][NH:27][CH2:13][CH2:12][O:11][C:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH:4]=[CH:3][CH:2]=2)=[CH:16]1

Participants

3

Reactant 2

HCID 289891H-indole-3-propylamineHCID 111833591-(2-chloroethoxy)naphthalene

Product 1

HCID 9862968HCID 9862968, compoundYield 85%

Procedure

This compound was prepared in the manner described above for Example 13 by replacing 2-(indan-4-yloxy)-ethylchloride with 2-(napthalen-1-yloxy)-ethylchloride (0.6 g, 2.8 mmol), and 3-(5-fluoro-1H-indol-3-y-)-propylamine with 3-(1H-indol-3-yl)-propylamine (1.35 g, 7.2 mmol) in 85% yield (1.42 g) as a yellow solid: mp 119-120° C.

Workup

  1. customThis compound was prepared in the manner

Sources & evidence

ORD record
ord-2b6640ce691c479f9733445069159578
Source dataset
uspto-grants-2000_09
Patent number
US06121307

Reaction notes

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