Tin tetrachloride → HCID 18430708, compound

Participants

Reaction Steps

Using 3,5-diisopropyl-p-anisic acid (5.0 g, 21.2 mmol, RN-117439-59-5), oxalyl chloride (2.2 mL, 25.4 mmol), N,N-dimethylformamide (2 drops), 2,3-dimethyl-5-benzylthiophene (4.3 g, 21.2 mmol), tin(IV) chloride (5.0 mL, 42.7 mmol), and anhydrous methylene chloride (82 mL) the title compound was prepared according to the procedure in Example 2, step 1 to give 4.1 g (45%) NMR (DMSO-d6) δ 7.47 (s, 2 H), 7.23-7.12 (m, 3 H), 7.02-6.99 (m, 2 H), 3.86 (s, 2 H), 3.73 (s, 3 H), 3.31-3.20 (m, 2 H), 2.27 (s, 3 H), 1.82 (s, 3 H), 1.15 (d, 12 H). MS(EI), [M+] 420.

Provenance & Evidence