Boron tribromide → HCID 18430727, compound

Participants

Reaction Steps

Using (2-benzyl-4,5-dimethyl-thiophen-3-yl)-(3,5-diisopropyl-4-methoxy-phenyl)-methanone (4.3 g, 10.1 mmol), boron tribromide (3.1 mL, 32.4 mmol), and methylene chloride (60 mL) the title compound was prepared according to the procedure in Example 2, step 2 to give 1.2 g (30%) as a yellow foam; NMR (DMSO-d6) δ 8.42 (s, 1 H), 8.24 (s, 1 H), 7.94 (d, 1 H), 7.48-7.32 (m, 3 H), 6.90 (s, 2 H), 3.45-3.35 (m, 2 H), 2.38 (s, 3 H), 1.57 (s, 3 H), 1.15 (d, 12 H). MS(-ESI), [M-H] 387.

Provenance & Evidence