4-(Chlorosulfonyl)-2-hydroxybenzoic acid → HCID 11827572, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure in Example 1, step 9, using 4-(2,3-dimethyl-naphtho[2,3-b]thiophen-4-yl)-2,6-dimethyl-phenol (2.052 g, 6.171 mmol) and 4-chlorosulphonyl-2-hydroxybenzoic acid (5.840 g, 24.68 mmol). Purification on 2% H3PO4 /MeOH treated Biotage KP-Sil, eluting with a 15 & 25% EtOAc/hexane step gradient gave 2.05 g (62%) of the title compound. 1H NMR (DMSO-d6) δ 1.60 (s, 3 H), 2.16 (s, 6 H), 2.42 (s, 3 H), 7.17 (s, 2 H), 7.38-7.40 (m, 2 H), 7.47-7.56 (m, 3 H), 7.98 (d, 1 H), 8.09 (d, 1 H), 8.50 (s, 1 H).

Provenance & Evidence