Nicotinic Acid → HCID 23295996, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure in Example 25, step 1, using 4-[4-(9-bromo-2,3-dimethyl-naphtho[2,3-b]thiophen-4-yl)-2,6-dimethyl-phenoxysulfonyl]-2-hydroxy-benzoic acid tert-butyl ester (0.500 g, 0.749 mmol), nicotinic acid (0.092 g, 0.749 mmol), 2-chloro-1-methylpyridinium iodide (0.230 g, 0.899 mmol) and triethylamine (0.251 mL, 1.80 mmol). Purification on Biotage KP-Sil eluting with 20% EtOAc/hexane gave 0.460 g, (80%) of the title compound. 1H NMR (DMSO-d6) 6 1.34 (s, 9 H), 1.55 (s, 3 H), 2.16 (s, 6 H), 2.36 (s, 3 H), 7.19 (s, 2 H), 7.45-7.46 (m, 2 H), 7.61-7.71 (m, 2 H), 8.12-8.25 (m, 4 H), 8.50 (ddd, 1 H), 8.94 (d, 1 H), 9.29 (s, 1 H).

Provenance & Evidence