Pyridine → HCID 53714433, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure in Example 17, step 1, using 4-[4-(9-bromo-2,3-dimethyl-naphtho[2,3-b]thiophen-4-yl)-2, 6-dimethyl-phenoxysulfonyl]-2-hydroxy-benzoic acid tert-butyl ester (0.500 g, 0.691 mmol), pyridine (0.335 mL, 4.15 mmol) and phenylacetylchloride (0.183 mL, 1.38 mmol). Purification on Biotage KP-Sil eluting with 3% EtOAc/pet. ether gave 0.272 g (51%) of the title compound. 1H NMR (DMSO-d6) δ 1.51 (s, 9 H), 1.56 (s, 3 H), 2.14 (s, 6 H), 2.43 (s, 3 H), 4.04 (s, 2 H), 7.18 (s, 2H), 7.27-7.37 (m, 5 H), 7.46-7.49 (m, 2 H), 7.66 (ddd, 1 H), 8.01-8.07 (m, 2 H), 8.13-8.21 (m, 2 H).

Provenance & Evidence