1-(Chloroacetyl)pyrrolidine → HCID 23296723, compound

HRID 1954348Notes

Reaction equation

HRID 1954348 reaction equation
[Na].[NH2:2][C:3]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:18][C:19](=[O:23])[N:20]([OH:22])[CH3:21])[CH:9]=[CH:10]2)[C:4]=1[C:24]([O:26][CH2:27][CH3:28])=[O:25].Cl[CH2:30][C:31]([N:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1)=[O:32]>>[NH2:2][C:3]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:18][C:19](=[O:23])[N:20]([O:22][CH2:30][C:31](=[O:32])[N:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)[CH3:21])[CH:9]=[CH:10]2)[C:4]=1[C:24]([O:26][CH2:27][CH3:28])=[O:25]

Participants

3

Reactant 2

HCID 884401-(Chloroacetyl)pyrrolidineHCID 86755844HCID 86755844, compound

Product 1

HCID 23296723HCID 23296723, compoundYield 77%

Procedure

In an analogous manner to that described in Example 1, from diethyl 2-amino-6-[(N-methyl-hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium and N-chloroacetyl-pyrrolidine the title compound is obtained in 77% yield as a wax.

Sources & evidence

ORD record
ord-c5bd906e857246a9b07586844582b17a
Source dataset
uspto-grants-2000_09
Patent number
US06121322

Reaction notes

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