Acetic Acid → HCID 23296620, compound

HRID 1954353Notes

Reaction equation

HRID 1954353 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([N:11]([S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:20])=[O:19])[CH2:12][C:13]([O:15]CC)=[O:14])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:27][CH2:28][C:29]1[CH:34]=[CH:33][C:32]([C:35](=[NH:37])[NH2:36])=[CH:31][CH:30]=1.[OH-].[Na+].C(O)C.C(O)(=O)C>O>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([N:11]([S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:20])=[O:19])[CH2:12][C:13]([OH:15])=[O:14])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:27][CH2:28][C:29]1[CH:30]=[CH:31][C:32]([C:35](=[NH:36])[NH2:37])=[CH:33][CH:34]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 23296599HCID 23296599, compound

Product 1

HCID 23296620HCID 23296620, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

0.52 g (0.93 mmol) of 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(ethoxycarbonylmethyl)-benzenesulphonylamino]-benzimidazole and 0.4 g (0.01 mol) of sodium hydroxide are stirred in 5 ml water and 10 ml ethanol for three hours at ambient temperature. Then the mixture is diluted with water and adjusted to pH 4 with glacial acetic acid. The crystalline precipitate is suction filtered and dried.

Workup

  1. filtrationfiltered
  2. customdried

Sources & evidence

ORD record
ord-8756f97155764491939c83950691715e
Source dataset
uspto-grants-2000_09
Patent number
US06121308

Reaction notes

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