HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-[2-(4-bromophenyl)ethyl]formamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl formate | HCID 8025 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Bromophenethylamine hydrobromide | HCID 2757090 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-[2-(4-bromophenyl)ethyl]formamide | HCID 23296214 | 93.1% |
Reaction Steps
500 g (1.78 mol) of 2-(4-Bromo-phenyl)ethylamine hydrobromide, 1 liter (12.4 mol) of ethyl formate and 248 mL (1.78 mol) of triethylamine were combined and heated to reflux for 3 hrs. The reaction was treated with 1 liter each of deionized water and ethyl acetate. The organic layer was separated and washed with 1 liter each of water and brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to yield 378 g of a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06121283 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-074a6603604648fdbd68e1a430e7520a |
| Source note | uspto-grants-2000_09 |