HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-Nitro-2-(phenylmethyl)-1,3(2H,4H)-isoquinolinedione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 2-(Carboxymethyl)-4-nitrobenzoic acid | HCID 7172025 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Nitro-2-(phenylmethyl)-1,3(2H,4H)-isoquinolinedione | HCID 23296179 | — |
Reaction Conditions
| Temperature | 115 °C |
|---|
Reaction Steps
To a suspension of the diacid (9) (55 g, 0.244 mole) in acetic acid (550 mL) was added benzylamine (28.91 g, 0.27 mole). The reaction was heated to 115° C. for 18 hrs., cooled to 25° C., water was added (450 mL), the contents stirred for 2 hrs., and the product filtered off as a white solid. The product was washed with water (400 mL) and vacuum dried to give 59.51 g (82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06121283 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-7076836b7d50455dbee75a7b54d10223 |
| Source note | uspto-grants-2000_09 |