HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4'-Trifluoromethylbiphenyl-2-carboxylic acid-(2-phenethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Phenylacetaldehyde | HCID 998 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 4'-Trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4tetrahydroisoquinolin-6-yl)-amide | HCID 11014758 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4'-Trifluoromethylbiphenyl-2-carboxylic acid-(2-phenethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-amide | HCID 15489613 | — |
Reaction Steps
A 400 mg (1.01 mmole) sample of compound (II), phenylacetaldehyde (121 mg, 1.01 mmole), sodium triacetoxyborohydride (320 mg, 1.52 mmole) and acetic acid (61 mg, 1.01 mmole) were stirred in 10 mL of 1,2-dichloroethane for 12 hrs. at ambient temperature. The reaction was diluted with methylene chloride, washed with 1N NaOH, water and brine. Purification was carried out with silica gel chromatography using 50% ethyl acetate/hexanes as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06121283 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-5a12cc7b815041c590e1496982ccc2f8 |
| Source note | uspto-grants-2000_09 |