HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenacyl bromide → HCID 131722009, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenacyl bromide | HCID 6259 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4'-Trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4tetrahydroisoquinolin-6-yl)-amide | HCID 11014758 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 131722009 | HCID 131722009 | — |
Reaction Steps
Compound (II) (0.30 gm, 0.76 mmole), 2-bromoacetophenone (0.15 g, 0.76 mmole) and potassium carbonate (0.12 gm, 0.83 mmole) were combined in 20 mL of acetonitrile and heated to reflux for 1 hr., and then the solvent was evaporated under vacuum. The residue was dissolved in chloroform and washed with saturated sodium bicarbonate. Purification of the dried organic layer was accomplished with silica gel chromatography using 50% ethyl acetate in hexane as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06121283 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-6eb7d6bc6b894be9a7d830064d0a8b0b |
| Source note | uspto-grants-2000_09 |