HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1954430Generated: October 27, 2026
Ethyl Acetate → 4'-Trifluoromethylbiphenyl-2-carboxylic acid-[2-(2-cyanoethyl)1,2,3,4-tetrahydroisoquinolin-6-yl]-amide
https://huagongshe.com/reaction/1954430
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 3-Bromopropionitrile | HCID 17020 | — |
| Reactant | 4'-Trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4tetrahydroisoquinolin-6-yl)-amide | HCID 11014758 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 4'-Trifluoromethylbiphenyl-2-carboxylic acid-[2-(2-cyanoethyl)1,2,3,4-tetrahydroisoquinolin-6-yl]-amide | HCID 23296216 | — |
Reaction Steps
Compound (II) (780 mg, 1.97 mmole), 3-bromopropionitrile (290 mg, 2.17 mmole) and 4-dimethylaminopyridine (264 mg, 2.16 mmole) were combined in 10 mL of DMF and heated to 70° C. for 72 hrs. The reaction was diluted with methylene chloride, washed with water and brine, and then dried over magnesium sulfate. Purification of the residue obtained on evaporation was carried out with silica gel chromatography using a gradient of 10-100% ethyl acetate in hexane as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06121283 |
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| Source dataset | uspto-grants-2000_09 |
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| ORD ID | ord-7c770732e71f44c5ae5359c5fda965f9 |
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| Source note | uspto-grants-2000_09 |
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