HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydride → Cericlamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydride | HCID 166653 | — |
| Reactant | HCID 11822623 | HCID 11822623 | — |
| Reactant | lithium aluminium hydride THF | HCID 68718528 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Cericlamine | HCID 131074 | — |
Reaction Steps
Process according to claim 1 or 4 in which 1.65 to 1.75 mol of amino ester (II) are reduced in toluene with a lithium aluminium hydride-tetrahydrofuran addition complex prepared starting from 1 mol of hydride, to obtain (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-ol (I) or cericlamine which is optionally salified with hydrochloric acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06121491 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-c524c4ff3f024b1889ec63e4ff64181f |
| Source note | uspto-grants-2000_09 |