6-Bromo-2-naphthalenol → Nabumetone

HRID 1954499Notes

Reaction equation

HRID 1954499 reaction equation
BrC1C=C2C(=CC=1)[CH:8]=[C:7]([OH:12])[CH:6]=[CH:5]2.Br[C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([O:24][CH3:25])[CH:18]=[CH:17]2>>[CH3:25][O:24][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([CH2:5][CH2:6][C:7](=[O:12])[CH3:8])[CH:23]=[CH:22]2

Participants

3

Reactant 2

HCID 271446-Bromo-2-naphthalenolHCID 787862-Bromo-6-methoxynaphthalene2×

Product 1

HCID 4409Nabumetone

Procedure

The process of claim 1 which also comprises methylating the 6-bromo-2-naphthol to 6-bromo-2-methoxynaphthalene and then converting the 6-bromo-2-methoxynaphthalene thus obtained to 4-(6-methoxy-2-naphthyl)-2-butanone.

Sources & evidence

ORD record
ord-6bb74647c22847e9b4b9a4c2b4c89e50
Source dataset
uspto-grants-2000_09
Patent number
US06121500

Reaction notes

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