反应详情

温度

60 °C

4-(S)-(1-Ethoxycarbonylcyclopropyl)-3-(S)-fluoro-1-[1-(S)-phenylethyl]-2-pyrrolidone (6.86 g, 21.48 mmol) was dissolved in dry toluene (100 ml), and the solution was mixed with Lawesson's reagent (5.21 g, 12.89 mmol) and heated at 60° C. for 30 minutes. After cooling, toluene was evaporated under reduced pressure, and the resulting residue was subjected to flash silica gel chromatography and eluted with an eluant of n-hexane:ethyl acetate=4:1, to thereby obtain 6.49 g (90.1%) of the title compound as a light yellow oil.

1. temperatureAfter cooling
2. customtoluene was evaporated under reduced pressure
3. washeluted with an eluant of n-hexane