cis-1-Benzyl-4-(1-tert-butoxycarbonylaminocyclopropyl)-3-hydroxymethylpyrrolidine → Cis-4-(1-tert-butoxycarbonylaminocyclopropyl)-3-hydroxymethylpyrrolidine

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Reaction Steps

cis-1-Benzyl-4-(1-tert-butoxycarbonylaminocyclopropyl)-3-hydroxymethylpyrrolidine (820.1 mg, 2.376 mmol) was dissolved in methanol (50 ml). After adding a 5% palladium-carbon catalyst (moisture content: 55.6%, 750 mg), the mixture was stirred under elevated hydrogen pressure (4.5 kg/cm2) over a period of one day and night. After filtering off the catalyst through celite (washed with methanol), the filtrate was concentrated under reduced pressure to obtain 578.8 mg (91.0%) of the titlle compound as a white amorphous substance.

Provenance & Evidence