HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanesulfonic Acid → HCID 23293363, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | 4'-Hydroxyacetophenone | HCID 7469 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 23293363 | HCID 23293363 | — |
Reaction Steps
4-Hydroxyacetophenone (75.00 g, 0.55 mol) was dissolved in ethyl acetate (300 ml) and a catalytic amount of methanesulfonic acid, and cooled to 0-4° C. Dihydropyran (204 ml, 2.20 moles, 4.0 eq) was slowly added. At room temperature, a white precipitate was formed, washed with water, and recrystallized from hexane. The yield was quantitative.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06123928 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-c8dffd03625a47e4b7eda8e7a798863e |
| Source note | uspto-grants-2000_09 |