1,2-Dichloroethane → 9-ethyl-9H-carbazole-3,6-dicarbaldehyde

Participants

Reaction Steps

109 g of DMF was cooled down to 0° C., and 228 g of phosphorous oxychloride was slowly dropped therein. The resultant was heated up to room temperature, and then 30 g of N-ethylcarbazole and 75 ml of 1,2-dichloroethane were dropped therein. The reaction of the mixture was carried out at 90° C. for 20 hours, thereafter the solution was cooled down to room temperature. The solution was poured into 1.5 l of ice water, and extracted with chloroform, dried with anhydrous MgSO4, and was separated with hexane and ethyl acetate in a column. The reaction yield was about 40%. The structure analysis was confirmed by 1H-NMR, which was shown in FIG. 6.

Provenance & Evidence