HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → HCID 178476396, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | HCID 178465153 | HCID 178465153 | — |
| Product | HCID 178476396 | HCID 178476396 | 40% |
Reaction Steps
Solutions of 40% leuprolide acetate (w/w) in DMSO were prepared, loaded into reservoirs, stored for two months at 80° C. and analyzed as described above. Results, shown in FIGS. 1 (RP-HPLC) and 2 (SEC) show that 81.1% leuprolide was recovered, with only 14.6% chemical degradation and 5.1% physical aggregation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06124261 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-7a22e22130bb4ff8ba40869835779b5f |
| Source note | uspto-grants-2000_09 |