Benzoyl chloride → HCID 23293551, compound

Participants

Reaction Steps

The product from Example 12 (5.00 g, 17.0 mmol) was dissolved in chloroform (70 mL), THF (30 mL), and 50 mL saturated aqueous NaHCO3 solution. The reaction mixture was treated with benzoyl chloride (2.5 mL, 21.5 mmol) and the water (25 mL). The reaction mixture was stirred for 5 days. The organic phase was collected, dried (MgSO4), and filtered. The filtrate was concentrated. The residue obtained was dissolved in hot THF and diisopropylether was added until a slight cloudiness developed. The solid which formed on cooling was collected by filtration, washed with additional diisopropylether, and dried under vacuum to give the title compound (4.78 g, 77%) as a white solid.

Provenance & Evidence