Phosgene → {3-[2-(2-Oxo-4,8b-dihydro-3aH-indeno[2,1-d]oxazol-3-ylmethyl)-4-trifluoromethyl-phenoxy]-phenyl}-acetic acid methyl ester

HRID 195481Notes

Reaction equation

HRID 195481 reaction equation
[CH3:1][O:2][C:3]([CH2:4][c:5]1[cH:6][c:7]([O:11][c:12]2[c:13]([CH2:22][NH:23][CH:24]3[CH:25]([OH:33])[c:26]4[cH:27][cH:28][cH:29][cH:30][c:31]4[CH2:32]3)[cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]2)[cH:8][cH:9][cH:10]1)=[O:34].[Cl:35][C:36]([Cl:37])=[O:38]>>[CH3:1][O:2][C:3]([CH2:4][c:5]1[cH:6][c:7]([O:11][c:12]2[c:13]([CH2:22][N:23]3[CH:24]4[CH:25]([c:26]5[cH:27][cH:28][cH:29][cH:30][c:31]5[CH2:32]4)[O:33][C:36]3=[O:38])[cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][cH:17]2)[cH:8][cH:9][cH:10]1)=[O:34]

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 67105364methyl 2-[3-[2-[[(1-hydroxy-2,3-dihydro-1H-inden-2-yl)amino]methyl]-4-(trifluoromethyl)phenoxy]phenyl]acetate

Product 1

HCID 58237561{3-[2-(2-Oxo-4,8b-dihydro-3aH-indeno[2,1-d]oxazol-3-ylmethyl)-4-trifluoromethyl-phenoxy]-phenyl}-acetic acid methyl ester

Sources & evidence

ORD record
ord-5820583480b541768d7e5d0043f19dd1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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