Ethanolamine → HCID 23293753, compound

HRID 1954847Notes

Reaction equation

HRID 1954847 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]([C:7]([O-:9])=O)[C:2]=1[C:10]([O:12]C)=O.[CH2:14]([CH2:16][NH2:17])[OH:15]>CCO>[OH:15][CH2:14][CH2:16][NH:17][C:7]([C:3]1[C:2]([C:10]([NH:1][CH2:2][CH2:10][OH:12])=[O:12])=[N:1][CH:6]=[CH:5][N:4]=1)=[O:9]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 23293748HCID 23293748, compound

Product 1

HCID 23293753HCID 23293753, compoundYield 131.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl pyrazine-2,3-dicarboxylate (2 g, 10.2 mmol) was dissolved in EtOH (3 mL). Ethanolamine (1.25 g, 20.4 mmol) was added and the mixture was heated under reflux for 6 h. After cooling the solvent was evaporated and the residue was purified by silica gel chromatography (EtOAc/MeOH, 3:1) to afford the title compound (1.7 g, 65.4%).

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 h
  3. temperatureAfter cooling the solvent
  4. customwas evaporated
  5. customthe residue was purified by silica gel chromatography (EtOAc/MeOH, 3:1)

Sources & evidence

ORD record
ord-ccc3690465a54a99a95edd7e45779133
Source dataset
uspto-grants-2000_09
Patent number
US06124298

Reaction notes

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